Brief introduction:
The intelligent integrated PAT crystallization platform integrates essential parameters required for optimizing the crystallization process, including concentration (supersaturation), particle size distribution, shape (crystal habit), crystal form, turbidity, temperature, and pH. The system is open and can be integrated with other PAT instruments, encompassing data acquisition, control, and key parameters.
Details:
This intelligent integrated PAT crystallization platform integrates real-time measurements of various parameters, data acquisition, and control. A deeper understanding of the crystallization process and product optimization requires online measurement of some of the most critical (basic) parameters, and the data needs to be integrated for correlation analysis. This platform integrates concentration (supersaturation), particle size distribution, shape (crystal habit), crystal form, turbidity, temperature, and pH. The system is open and can be integrated with other PAT instruments. Crystallization conditions can be automatically controlled (precise automatic control ). Crystallizers of different sizes are available. It is the best assistant for product development and process scale-up.
The platform integrates measurement and control:
- Concentration (supersaturation)
- Particle shape and particle size distribution
- Crystal form transformation, nucleation points, agglomeration, fragmentation, twinning, morphology and grain size control, seeding, etc.
- Parameters such as turbidity, temperature and pH value
- Intelligent closed-loop automatic control
Basic configuration of the intelligent crystallization experimental platform:
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serial number |
Product Name |
Product Introduction |
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( a1 ) |
Pharmavision On-line imaging probe for particle shape and size characterization |
• Real-time on-line measurement of crystal morphology and particle size distribution (PSD) evolution over time. • Enables real-time visualization of critical crystallization phenomena such as nucleation, polymorphic transformation, amorphous phase formation, onset of crystallization, agglomeration, and crystal breakage. |
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(a2) |
NanoSonic Probe-type ultrasonic particle size analyzer |
• Real-time on-line measurement of particle size distribution ranging from 1 nm to 3 mm. • Capable of detecting nucleation-scale particles, generating a PSD within <5 seconds. Few instruments can perform real-time in-situ nanoparticle measurement. • Provides true particle size measurements, not values inferred from chord length distributions. |
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(a3) |
Turbidity Probe Turbidity meter (Turbidityᵖʳᵒᵇᵉ) |
• Real-time on-line turbidity measurement for determining crystallization onset point, solubility, and metastable zone width (MSZW). |
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(a4) |
JGM ATR FTIR On-line infrared spectrometer |
• Measurement of solute concentration and supersaturation. |
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(a5) |
JGM RAMAN On-line Raman spectrometer (JGM Raman) |
• Rapid in-situ identification of structurally similar species, including hydrates, isomers, polymorphs, polymorphic transformations, and amorphous-to-crystalline transitions. |
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(a 6 ) |
Crystal MPB software |
• Proprietary crystallization process simulation software. |
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( a 7) Note |
Crystallizer with cooling device Thermometer, pH meter |
• 2 L crystallizer equipped with temperature control system, temperature probe, and pH probe. |
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(a 8 ) |
SHAPE image processing software |
• Advanced particle image analysis software with extensive processing functions. |
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